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We introduce volumetric DNA microscopy, a way that allows three-dimensional imaging of tissue morphology and gene expression in a single measurement. This feat is achieved by forming an enormous intermolecular community of DNA barcodes inside an intact specimen and encoding their pairwise proximities right into a DNA sequence library.
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This can be a abstract of: Qian, N. & Weinstein, J. A. Spatial transcriptomic imaging of an intact organism utilizing volumetric DNA microscopy. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02613-z (2025).
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Volumetric imaging utilizing a distributed molecular community.
Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02640-w
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DOI: https://doi.org/10.1038/s41587-025-02640-w
